Well, there is one way to "cheat" that, Cathar, which is to spend lots of money. Peltiers can offer a great boost to thermal performance while keeping space consumption low. If you can fit the high current power supply in the solution, you can use a much smaller radiator and/or pump. Also, adding peltiers does reduce the system reliability and the resilience to failure for the system. Any peltier failure basically means replacing the CPU, motherboard and maybe nearby components unless you have some darn good watchdog electronics.
But, it's all tradeoffs. There is no "perfect" design, as Cathar correctly states.
Edited to add more components that a peltier can destroy in a failure mode
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