I will say from experience that I have designed and built 4 copper waterblocks all very similar to ECUPirate's diagram above. There are only 4 channels in each block but the rest of the design is similar, all channels are of equal size.
I have compared my blocks to DD Maze 2, Maze 1 and the jagged edge block(forgot who makes it). Using the identical system and testing parameters, my block performed equally or better than all of the blocks above. I don't have a lot of fancy graphs and pictures to show because I did the testing mostly for my own curiousity. That being said, a different radiator or pump combined with each block may have yielded different results.
For this reason, I have always believed that having the inlet over the center of the block is generally a waste of time and effort. With the exception of the spirals, it almost always leads to a design with a lot of flow restriction. We all know that poor flow through the block is not a good thing.
IMHO the best block is a straight through, one pass design with maximum flow through the center of the block.
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