About designing it for the pump, MadDogMe is referring to this: get the PQ curve for the pump. You will likely find a curved line. Draw a line at the axis intersects, and see which point on the curve is furthest away from your line: that's your pump's point of maximum efficiency.
Then, design your block to operate with those parameters. If you use a heatercore, you have to account for it too, and I can tell you right now, the result/parameter is actually different.
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