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Originally Posted by kronchev
can I just swap out refrigerants and not really worry about the systems design? Or do certain R's only work in certain systems?
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You have to learn your R's. The compressor has to be able to produce enough pressure for the gas in question, the capillary tube needs to be have a length/ diameter appropriate for your gas's viscosity and pressure drop. The system has to be charged with an amount specific to your system.
Without that specific knowledge,
:shrug: The only workable substitution I know of is R134 for R22, which involves a slight performance hit.