Heatercores should be in parallel, not series.
Might want to include northbridge cooler on loop#2, as this is not a point that produces a lot of heat.
If you dig around the forums you'll find a slew of homebrewed HD watercoolers that may well be cheaper (and possibly better performing) than what you could buy. It doesn't take much to keep them cool.
If you're building a radbox, it might be worth your while to incorporate a reservoir. They make filling/bleeding a whole lot easier.
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