Depends upon the pump you buy. If you get an Iwaki of sufficient power, sure, you can go with one pump, it'll just be pretty damn big. Or you could get a couple Laing D4/MCP650's and run them in series, or even better, set up a separate CPU loop and NB/GPU loop and use two rads. A single 120mm would be fine for the NB/GPU and a dual heatercore would be best for the CPU. If you have decent airflow you shouldn't need to watercool your hard drives since you'll have nothing in your case adding to case air temps.
Copper pipe, while nice looking and potentially beneficial to your temperatures (though probably not measurably so) will most likely be more work than is actually worth. Not to mention routing all of it with that much stuff in your loop(s) would be insane. CPU/NB/GPU/HDs with copper tubing? Madness.
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