I assume even nano particles will build up over time. Especially if there is a large enough amount to actually effect thermal conductivity.
Anyway if this stuff ever came out it would be so expensive normal people like us wouldn't be able to afford it anyway.
Hell, plain water still hasn't gone mainstream. We still have to wait for air to stop working and then go through years of mainstream water cooling evolution and then it will be better liquids. This is provided the CPU companies stay on track of making hotter CPU which seems to not be their goals.
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