I'm still trying to figure out what type of core you have. When I look at
www.heatercore4u.com/Make.htm it shows all ford P/U trucks as having top tanks (two pass) like this:
XOXXX0X
XXXXXXX
XXXXXXX
XXXXXXX
XXXXXXX
TTTTTTT
Where the O's are the tubes and the T's are the bottom tank (looking straight on). This is desirable.
There are some that are one pass - in top and out bottom (or side to side depending on how mounted). You don't have one like this do you? As the water spends less time in the core to actually cool.
It doesnt't matter that much how you mount the core, as sooner or later all the air will leave with your 500gph pump and 1/2". Flow will be complete then regardless of position. If it's sideways, auto's usually have the Inlet higher than the outlet, as this promotes hot water staying in the core. I doublt it amkes a difference.
Lastly I'm just using a single 120mm Delta Fan (107cfm) although it works well, JimS has a better setup. I made a fan shroud and saw 2-3 degrees (but it was in the way) so I may copy him with 4 cheap, quiet 80's. You need some way to have airflow corner to corner, or hot water just bypasses on corners.