Filling without a reservoir is much slower, and without an airtrap (which a reservoir can do, too), you have to shake your system around. But, it will work just fine. I have a system using a TDX, DD GPU block, DD res, BIX2 and D4 pump. It is a fine system and keeps temps down very well but it is not silent.
NOTE: I am not saying other manufacturers aren't good, as I have other equipment by other manufacturers, and some home-made stuff too.
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