the obvious, 1/2" is less restrictive and 3/8" is easier to work with. i think someone did a comparison with the two sizes and found that there really was no difference. however, i do not recall what hardware they were using so it may or may not be relevant to you. nevertheless, if you plan to have three blocks, the smaller tubing might be the way to go unless you have a particularly roomy case. i doubt it'll hurt you seeing as how you'll be using two pumps.
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