Always remember, single-pass isn't always best, especially for water-cooling loop scenarios.
Works okay/well for single-core (one row of tubes), but for dual-core (two rows of tubes) it may turn out worse as per-tube velocity drops too low.
As with all things, there is a time and place for them dependent upon the application. If single-pass were always better for dual-row cores, then all dual-core heater-cores would all be made single-pass by the car manufacturers, but they're not.
Car radiators are single pass because they have flow rates high enough to keep per-tube velocity up high enough to make it worthwhile, which is why they typically have 1" ID ports on them.
The PA160 was single-pass because it is a single-core radiator.
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