For me at least the Tygon 3603 seems a lot more durable both mechanically and chemically than the clearflex. I used Clearflex in one of my systems but the tubing quickly clouded up so I switched everything to Tygon except for one tube. The Tygon has remained perfectly clear over the last two years while the Clearflex tube became almost completely opaque. I have no idea why it happened, I run normal distilled water and Zerex, but it did happen.
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