Re: New High End Build...Two Loops?
Dont complicate this!! Just route the tubing the easiest way possible with the fewest major bends. The order of the placement will have VERY little impact on the cooling capacity. I'd go pump>dual rad>CPU>GPU1>GPU2>single rad>Pump judging by your picture.
In actuality, you shouldnt need that extra 120mm radiator at the bottom. I'm fairly certain a dual 120mm BIP would suffice for your system.
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