i remember the stats on the 80mm BIpro rads and especially the single 80s had an insignificant heat disipation
the 80 will have a higher flow restriction also
consider that every 90 degree turn in your loop is equal to about 6-10 feet of straight hose and that double pass rads contain 2 90 and 1 180 degree turns and that the 80 is much narrower than the 120s
you should get the best results from the 120s and bigger is better
1 320 should perform better than 1 220 & 1 120 when flow restriction is considered
i haven't been following pumps lately but last i had heard the
MCP355 was a great pump with a lot head and very quiet
when you add the after market
delrin top you get more flow and almost as much head
i think this pump is in a similar price range as the D5 which if i remember correctly also sells as the MCP655?
also adding a 2nd pump may not increase performance as the heat dump from the pumps is doubled and the cooling efficiency is fairly constant at all flow rates (it does increase but not significantly so)
it would help if you told us what your goals are
cost and price range?
OC potential?
noise tolerance?
normal best case is pick 2
j
ps it would be best to route your cooling loop with as few bends and the shortest possible length of hose you can use
there are many many posts on this site explaining why rad location in the loop has little affect on the temps of the component following it
skip the HDD cooling; get an ultra quiet fan blowing on the drive and run it at 7v and you will be happier