If your running a high flow system (300GPH+) with decent flowing blocks and rad then daisy chaining shouldn't hurt much. The water will only heat up 1C-2C at most when leaving the first block which could come out to be 3C-5C Difference in temps. As long as your not trying to get 1.7Ghz out of them it should be ok.
I personally would run them in parralel with a high flow pump.
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