There are standard equations for rectangular vents for calculating the flow resistance they present. There are also equations for calculating the effect of the turns in the channels (and yes, those turns will have an effect).
Regarding making the channels significantly larger than 1/8th the opening port size, you run into 2 problems, both significant. First, because of the very large differences in channel length and turns, you would indeed end up with very low flow in the last 4 channels (farthest from the outlet). More than 80% of the flow would go through the first 4 channels if they are double sized.
The second problem is that you will be slowing the velocity of the water down to less than 50% of what it is at the inlet. You would end up with a large boundary layer of water against the block surfaces and poor heat flow into the water unless you used a high pressure, high flow pump. (you would still be losing velocity, but you could get enough to at least keep semi-decent thermal flux going)
Digital's description of an alternate way to solve a lot of those problems, with small radial channels and a "second tier output combiner" is probably an easier solution. There's a thread in here somewhere that he and I were discussing just such a concept that has a drawing I posted up that will give you an idea of what he means.
DC, you remember what thread that was in bro?
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