It depends on components and what results you will accept. It seems that the Maze2 and Maze3 like high flow even with a less restrictive heater core or the BIX. Actual flow from an Eheim 1250 with a Maze2, 6 x 6 heater core and 1/2 lines is 95GPH. I dropped the line size to 3/8," actual flow drops to 64GPH and my CPU temp goes up 1C. Using restrictors to slow the flow to 55GPH gets me another 1C increase in temps.

While I haven't flow tested it yet, replacing that 3/8" ID outlet on the 1250 with a modded fitting that gets me to 1/2" without a 3/8" adapter resulted in a 1C decrease in loaded CPU temps.
So if you want the best temps possible, increased flow with certain components is the way to go. If you just want acceptable temps, less flow is fine.