Epoxy won't be the best solution, any Pelt requires heavy clamping to work at its best, and this can only be done, ironically, with metal screws.
'tis best to clamp, then isolate.
That WB design (1st one) is best for cooling a core, as it receives cold coolant in the middle, in line with the CPU core.
The channel design is best for Pelts, because the heat is spread out more evenly.
You must work around the channels, by making a fat corner for the clamps to the cold plate. Where there's a will, there's a way.
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