Pressure in my system is the last thing I worry about (though i don't have a res - fewer places to leak). In fact, when I put additives in my system I increase and decrease the overall pressure of my system considerably in order to mix it. With the computer off (but the pump on - I just don't want to worry about temps/flow-rate during this) I grab as much of the tubing as I can at once, and squeeze it almost flat - causing the water-level in my air-trap-tube to rize a bunch, and causing the additive I put in in to mix around with the newly added liquid. Then (a couple seconds later - I'm not gonna damage the pump by stopping flow for a very short time) I release the tubing, and sqeeze the tube of my air-trap almost flat (or as much as I can without squeezing air down into the system). This forces as much of the concentrated mix as I can into the actual cooling loop. I repeat this a few times and then let the pump even the mix out, which seems to take a few hours for good even coloring. And so - I'd recommend just capping your res tight and sealing the system. If it fills up with air that you missed during the initial fill (which will happen - I don't think it's possible to get ALL the air out when you first fill it) - open the cap, top up the coolant again, and re-seal it. A good seal not only stops evaporation, but also keeps bacteria from getting in. (a seal won't stop bacteria in the system from starting to grow, but if no new organism's can get in it can't hurt).
And yes, the ViaAqua 1300 is submersible - I have one. And it runs well in-line - that is how I'm running mine.
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