i think the most economical way to test these theories would be to make blocks out of aluminum. its cheap, readily available, and easy to mill/machine/drill/do whatever too :]. Comparisons of temp readings using diff aluminum blocks could be compared, and then a final design could be sent to a machinist to make a copper block.
and would a high pressure drop really matter if you're using a system with a resevoir? the resevoir isn't maintained at the same pressure as the pump, so while the water pressure is reduced going out of the cpu block, wouldnt it all return to normal as the pump takes from the res?
I think there isn't just one design to the ultimate block, the real consideration lies in what other components you use. Of course this is all theory anyway, but I thought I'd throw in another opinion.
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