In my design (which is not the most efficient) I calculated 3 fittings in terms of impact to flow. I felt safe with this design as my pump is rated to overcome significant back pressure.
I went with this configuration for the sake of expediency and ease. In your design (from what you have shared so far) I would venture to guess that overcoming resistance to flow will be an issue. Bleeding the system may also be an issue. I would go with simplicity and test the system using a fill tube at first before moving forward with an air trap.
Cheers!
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