Hey MadDog,
As you probably know, a centrifugal pump (like the E-1250) creates a high pressure area at the discharge and a low pressure area at the suction. The diff pressure causes water to flow thru the system. Cavitation can occur in the low pressure area where water enters the pump impeller.
Are you running a closed loop system without a reservoir?
Are you using Silicone tubing?
If Yes... one situation I have seen is the system will gradually loose water over time due to the relatively high permiability of Silicone to water vapor. If you don't have a reservoir or fill tube to replace the lost water the system will actually start operating under a low vacuum. Air can be sucked into the pump inlet fitting and cause cavitation like noises. If the system is sealed really well so no air can leak in, it may be possible for the pressure to drop enough to actually cause the pump to cavitate.
I hope you get to the bottom of this and solve your problem.
RoboTech
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