Acetone is generally regarded as a universal solvent for plastics, and I think others have established its danger. The fact that it has such a high vapor pressure means the acetone concentration in your system would drop significantly anytime the system was allowed to vent. The vapor would also be mostly acetone, so mixing it in low concentrations with water may still make vapor that is highly flammable and toxic.
Unless it has astounding heat transfer properties (which is unlikely, since pure acetone is quite dismal compared to pure water) I can't imagine why someone would bother going through the effort of building a solvent-proof system.
I'd personally use ethylene glycol for sub-zero cooling. Perhaps not the best heat transfer properties, but still quite good, and very kind to your WC components.
Alchemy
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