I think it'd be best with a single S design. The copper tube shouldn't be much of a restriction (if 1/2 or larger).
As for size, it's hard to tell, but I'd go ahead and fill a 1U height with it (12 inches deep? by 19 inch wide)
The problem is that if you want airflow from front to back, you'd be better off with an S design, where the water flows in the opposite direction of the air, if you know what I mean.
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