It depends. For blocks that have an inlet above the core and don't artificially restrict the inlet further (for example - the White Water block artificially restricts the inlet further so it doesn't fall into this category, whereas the Swiftech MCW-462U does), then 3/8" tubing can be better as it offers a faster jet of water onto the hottest sections of the block.
For pretty much everything else, 1/2" is better as it offers less restrictions leading to higher flow rates and hence cooling performance.
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