my 0.02 cents.
1) No.
2) 200l/h without restrictions is too low, get at least a 1046 (personally i'd get a 600l/h at least) or similar. The bix and the papst and one of those blocks , it will work. Are you using the same reservoir or none, or an independent one?
3) No. The 2x 120mm is more efficient, and puts out more cfm than those 4x 80mm , assuming the fans are decent (the 120mm ones that is).
4) That depends, if you use that way, you have a bit higher flow into the cpu block.
You can use pump->rad->cpu->res to have the coolest water reaching the cpu.
Both systems work good, the rest is up to you.
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