Explosion proof. Yeah. Good luck finding explosion proof USB connectors, 15 pin D-sub, and 1/8" audio plugs. A better bet would be to build a sealed box around the ports and pot the lines passing through the box.
A dessicant is fine as once you get everything sealed (or go with net positive pressure) you should theoretically have no further intrusion of moisture. In those events where you break into the case, the dessicant can typically be recharged by a brief stint in the oven. It's only real job is to "clean up" the moisture left over when you close the seal.
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