I'm surprised that gmat hasn't made his negative pressure speech yet! In any case, positive pressure is what is required here: Only a minor pressure should do, and it would be easier to keep the system filled, if there's a leak.
So which dry gas is cheaper to get? Is it nitrogen? What about CO2?
Joe: I think that Argon (or other noble gas) isn't necessary, because he's doesn't need to use a chemically inert gas here: I don't think there's any expected reaction. I like the CO2 idea.
As for cooling the insides, it's only needed to compensate for the heat generated by the mobo. As pHaestus pointed out, a waterblock will still dissipate up to 20% of its heat in the surrounding air, so if we're talking about a CPU making 100W, the cooling solution would need to pick up 20 Watts. To that, add a few watts for the ram, and then there are those MOSFETs, chipset, etc...
Seeing that the heatload isn't insignificant, I would opt to use a heatercore inside the tube, for a more efficient heat transfer, instead of a copper tube. This is where a BIX would be nice, because it's small.
This is getting interesting. I never thought I'd see a heatercore used "in reverse", for a PC!
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