Rad does make a difference, it depends if you water cool CPU only or cool Cpu, NB, SB, Video card, etc.
Then you will need a bigger Rad or Dual ones.
Im just cooling my CPU so a 6x6x2 from D-Tek will do me fine.
I could probably split the line from rad and cool Cpu and something else (video card).
Right now using a Vantec all Copper kit on NB(NorthBridge) and that works fine for me.
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