Welcome to ProCooling!
There are two factors that will impact your performance: the added heat from the NB and GPU, and the flow restriction, from these two blocks.
Usually, you can minimize the impact on flow with a low restriction block, such as DangerDen's, especially their GPU model. The actual impact on your CPU temp is going to depend on the block's design.
As for the increased heatload, it depends! The latest video cards (NVidia GeForce FX excluded) have a relatively low power emission, but just enough to raise your CPU temps by a degree or two. OC'ing it will raise the heatload.
As for the NB, again, it depends! The latest NVidia NForce2 does run very hot, especially if it's overclocked. You can bet on a couple of degrees there too.
Overall, your cooling solution should be able to handle the extra heat, unless you have a very small heatercore in which case, the CPU temp might again, go up a couple of degrees. Usually, you can maximize the efficiency of the core with dual fans, turned up a little higher (if you've got them running low).
Good luck, and measure your water temp!
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