Absolutely.
You must have three things:
the pressure drop curve for the heatercore/rad
the pressure drop curve for the block
the PQ curve for the pump.
As long as you keep the flow speed less than 2 or 3 feet per second within the tubing, you can basically ignore it (unless you want to be accurate).
You then add the pressure drops for the block and core, overlay this total over the pump curve, and see where the lines cross: that's your resulting flow rate and total pressure drop.
It's easier said than done, but that's the principle. I usually run the numbers at different flow rate increments.
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