Since you'll be making your own NB and GPU block, the actual flow resistance isn't known, but in what's commonly available, it isn't hard to see that even a DD Z-chip block would be less restrictive than a lot of waterblocks. If you design your NB and GPU blocks specifically to be restrictive, then that'll change everything.
I don't see 2 * Eheim 1250 in series, on that last graph, but I can see that Since87 did account for a certain loss, in the "serial" application, which is correct.
Otherwise, I have to agree: in a dual setup, putting the CPU blocks in series appears to be best.
You could run some flow/pressure tests on those blocks you're making, and recalculate what would perform best.
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