Changing the coolent I don;t think will have any bearing on the performance.... to get better heat conduction than what we are already getting we may have to rethink thinngs and consider other ideas.
NB: I am not talking active cooling but the perfect mix of materials and chemical that get enargy (stored as heat) from point A to point B as efficiently as possible.
Maybe:
Heat pipes are very good at transfering heat... I have one on my GPU (Zalamen) and to be honest both sides increase in temperature at virtually the same rate.
Of course you would have to do a LOT of research but maybe you use it in conjunction with a water block helping remove excess heat from the baseplate to another place to cool it, or make the tubing into a conductor for heat... a sort of flexible heat pipe?
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