It's certainly not optimal. Consider that the 1/4" barbs will probably have an ID of 1/8". For the 1/2" barb the ID is around 3/8", so you just restricted flow by another 33%. If at all possible, I would try using a waterblock with a single inlet and two outlets (the whitewater is an example) and then use 3/8" hose for the runs from the two outlets to the GPU and NB. This should give you a fair bit more space. You can also take a drill and widen the ID of the hose barbs to increase flow rates.
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