I think you're going to get everyone defending their setup here... but, anyway...
I have all-SCSI, and I think the main disadvantage is price. I definitely like it better than my previous IDE setup, it *seems* to be faster. I never benchmarked. :P
One thing I can do w/ SCSI that I can't do easily w/ IDE - when I formatted my harddrive, it was much faster to copy stuff from my backup CD (tons of MP3's, etc.) - I had 2 CD's going at a time and my system wasn't in "super-IDE-lag mode." Kind of a weak reason to get SCSI, though. :P
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